DAO Enzyme

$49.00

$49.00 $49.00

Promotes breakdown of dietary histamine‡
Eat with greater confidence when histamine may be present in food‡
Reduces gastrointestinal discomfort (occasional diarrhea, bloating and gas) associated with sensitivity to histamine-rich foods‡

60 Capsules

$49.00

$49.00 $49.00

FREE SHIPPING (1-4 Business Days)

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Free From ...

Pure Encapsulations® products are formulated using high-quality, pure ingredients, FREE FROM unnecessary additives and many common allergens including:

Wheat, soy*, dairy*, eggs

Artificial Colors & Sweeteners

Coatings & Shellacs

GMOs††

Tree Nuts, Peanuts & Sesame

Unnecessary Binders, Fillers & Preservatives

Magnesium Stearate

Gluten

Trans Fat & Hydrogenated Oils

Sleep
Digestive Support

Histamine is a substance found in many foods, such as meats, spinach, fermented foods, avocadoes, nuts, tomatoes and chocolate. An estimated 1-3% of the population cannot digest dietary histamine efficiently, often because of low intestinal diamine oxidase (DAO), an enzyme in the GI tract that normally breaks down histamine. These individuals often experience gastrointestinal discomfort, headache, skin sensitivity or flushing after consuming histamine-containing foods.¹ Supplementation with DAO enhances DAO activity in the GI tract, promoting breakdown of dietary histamine and reducing gastrointestinal discomfort (occasional diarrhea, bloating and gas) associated with sensitivity to histamine-rich foods.³ DAO may also reduce skin symptoms associated with high intestinal histamine levels.⁶

In an open-label pilot study, individuals with low DAO levels (< 10 U/ml) who received DAO (10,000 HDU) up to 3 times per day reported significant improvements in gastrointestinal, respiratory and skin symptom scores after 4 weeks. Subjects reported significant improvement in gastrointestinal comfort, including occasional diarrhea, bloating and gas, headache, respiratory and skin discomfort.³ In a double-blind, placebo-controlled, crossover investigation of 22 patients, supplementation of 10,000 HDU DAO twice daily for 30 days improved dietary histamine-associated skin discomfort.⁶‡

References

1. Comas-Basté O, Sánchez-Pérez S, Veciana-Nogués MT, et al. Biomolecules. 2020 Aug 14;10(8):1181.

2. Sánchez-Pérez S, Comas-Basté O, Costa-Catala J, et al. Front Nutr. 2022 May 25;9:897028.

3. Schnedl WJ, Schenk M, Lackner S, et al. Food Sci Biotechnol. 2019; 28(6): 1779-1784.

4. Manzotti G., Breda D., Di Gioacchino M., Burastero S.E. Int J Immunopathol Pharmacol. 2016;29:105–111.

5. Komericki P., Klein G., Reider N., et al. Wien Klin Wochenschr. 2011;123:15–20.

6. Yacoub MR, et al. Int Arch Allergy Immunol. 2018;176(3-4):268-271.

Overall rating: 4.923077 / 5 from 13 reviews.

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Review topics: [encapsulations team].

Review highlights

Reviews

Dear Pure Encapsulations Team, I

"Dear Pure Encapsulations Team, I am writing to express my sincere appreciation for your products. I have histamine intolerance and experience severe hives when consuming MSG, preservatives, sulfites, and a wide range of ingredients including various Asian condiments, certain fruits, and vegetables. To enjoy meals out without these reactions, I rely on your DAO and Digestive Enzymes supplements. After researching and trying several other brands, I have found that Pure Encapsulations provides the most effective and clean products available. While they are a higher investment, the quality and results are worth every penny. Thank you for providing such reliable products. I am a faithful customer and truly trust your brand."

— Ada W. (5/5)

It came on time and

"It came on time and bottle in perfect condition, but I haven’t used the vitamin yet to rate the actual product!"

— Varai U. (5/5)

The package took too long

"The package took too long to arrive — it looks like the company is using a new delivery carrier. Not good."

— Francesca P. (4/5)

Excellent Product

"Works better than the others I have tried."

— Katharine F. (5/5)

Working very good!!!

"Working very good!!!"

— Misty A. (5/5)

Works for me

"Works for me"

— James D. (5/5)

Good product

"Works well"

— Shay R. (5/5)

They are good.

"They are good."

— Janie H. (5/5)

Thanks

"Thanks"

— Kathy H. (5/5)

DAO experience

"My symptoms were, even when eating healthier than I ever have (62 year old female), immediately after eating my throat would swell enough to make it hard to swallow. I felt like something was blocking my throat. I would become bloated for a few hours and felt uncomfortable. I had an endoscope procedure and there were no significant findings. My throat didn’t need stretching, no abnormalities. I was offered to go on an acid reflux medicine, but my doctor explained the side effects of long term use. So I did research with the Pure Encapsulation platform and came across the DAO Enzyme supplement. It addressed my symptoms and I really recognized that after I ran out of my first bottle. Within days, symptoms reoccurred. I am back on it and grateful for it!"

— Christine B. (5/5)