Hives are getting better!
"I get night sweats from menopause and that causes me to get hives. Since I’ve started using DAO, the hives have almost gone! This is a blessing in a bottle for me."
Product Information
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Digestive Support
Histamine is a substance found in many foods, such as meats, spinach, fermented foods, avocadoes, nuts, tomatoes and chocolate. An estimated 1-3% of the population cannot digest dietary histamine efficiently, often because of low intestinal diamine oxidase (DAO), an enzyme in the GI tract that normally breaks down histamine. These individuals often experience gastrointestinal discomfort, headache, skin sensitivity or flushing after consuming histamine-containing foods.¹ Supplementation with DAO enhances DAO activity in the GI tract, promoting breakdown of dietary histamine and reducing gastrointestinal discomfort (occasional diarrhea, bloating and gas) associated with sensitivity to histamine-rich foods.³ DAO may also reduce skin symptoms associated with high intestinal histamine levels.⁶
How To Use
Science & Research
In an open-label pilot study, individuals with low DAO levels (< 10 U/ml) who received DAO (10,000 HDU) up to 3 times per day reported significant improvements in gastrointestinal, respiratory and skin symptom scores after 4 weeks. Subjects reported significant improvement in gastrointestinal comfort, including occasional diarrhea, bloating and gas, headache, respiratory and skin discomfort.³ In a double-blind, placebo-controlled, crossover investigation of 22 patients, supplementation of 10,000 HDU DAO twice daily for 30 days improved dietary histamine-associated skin discomfort.⁶‡
References
1. Comas-Basté O, Sánchez-Pérez S, Veciana-Nogués MT, et al. Biomolecules. 2020 Aug 14;10(8):1181.
2. Sánchez-Pérez S, Comas-Basté O, Costa-Catala J, et al. Front Nutr. 2022 May 25;9:897028.
3. Schnedl WJ, Schenk M, Lackner S, et al. Food Sci Biotechnol. 2019; 28(6): 1779-1784.
4. Manzotti G., Breda D., Di Gioacchino M., Burastero S.E. Int J Immunopathol Pharmacol. 2016;29:105–111.
5. Komericki P., Klein G., Reider N., et al. Wien Klin Wochenschr. 2011;123:15–20.
6. Yacoub MR, et al. Int Arch Allergy Immunol. 2018;176(3-4):268-271.
Reviews
Overall rating: 4.9333334 / 5 from 15 reviews.
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Review topics: ["encapsulations team"].
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Reviews
Dear Pure Encapsulations Team, I
"Dear Pure Encapsulations Team, I am writing to express my sincere appreciation for your products. I have histamine intolerance and experience severe hives when consuming MSG, preservatives, sulfites, and a wide range of ingredients including various Asian condiments, certain fruits, and vegetables. To enjoy meals out without these reactions, I rely on your DAO and Digestive Enzymes supplements. After researching and trying several other brands, I have found that Pure Encapsulations provides the most effective and clean products available. While they are a higher investment, the quality and results are worth every penny. Thank you for providing such reliable products. I am a faithful customer and truly trust your brand."
Love it!
"Love it!"
It came on time and
"It came on time and bottle in perfect condition, but I haven’t used the vitamin yet to rate the actual product!"
The package took too long
"The package took too long to arrive — it looks like the company is using a new delivery carrier. Not good."
Excellent Product
"Works better than the others I have tried."
Working very good!!!
"Working very good!!!"
Works for me
"Works for me"
Good product
"Works well"
They are good.
"They are good."