Product Information
-
Vitamins & Minerals
Folate 5,000 provides 5,000 mcg of folate as 5-methyltetrahydrofolate (5-MTHF), the universally metabolized and biologically active form of folate.<sup>1, 2</sup>
How To Use
As a dietary supplement, take 1 capsule daily, with a meal, or as directed by a health professional.
Science & Research
Genetic variations affecting activation and metabolism of supplemental folic acid are highly prevalent.<sup>3</sup> Through bypassing several enzymatic activation steps catalyzed by DHFR (dihydrofolate reductase) and MTHFR (methylenetetrahydrofolate reductase), 5-MTHF is directly usable by the body and provides all of the benefits of folic acid regardless of functional or genetic variations in these enzymes.<sup>4</sup> At the molecular level, the main function of folate is to donate methyl groups in key biochemical reactions occurring in blood cells, neurons, the vasculature and many other tissues.<sup>5</sup>,<sup>6</sup> In addition, folate promotes the production of healthy DNA.<sup>7</sup>‡
References
1. Prinz-Langenohl R, et al. Br J Pharmacol. 2009 Dec; 158(8): 2014–2021.
2. Lamers Y, et al. Am J Clin Nutr. 2006 Jul;84(1):156-61.
3. Yang Q, et al. Am J Clin Nutr. 2012;95(5):12451253.
4. Seremak-Mrozikiewicz A. Ginekol Pol. 2013 Jul;84(7):641-6.
5. Terry MB, et al. Epigenetics. 2011. 6(7); 828-37. Stanhewicz AE, et al. Clin Sci (Lond). 2015 Jul;129(2):159-67.
6. Duthie SJ. J Inherit Metab Dis. 2011 Feb;34(1):101-9.